Description: Eletriptan is a selective serotonin receptor agonist (triptan) used to treat acute migraine headaches in adults, with or without aura. It is not intended to prevent migraines. It is a second-generation triptan that is often available in oral tablet form.

Indication: Eletriptan is specifically indicated for the acute treatment of migraine attacks. It should be taken as soon as a migraine headache begins, and is not effective if taken beforehand to prevent an attack.

Mechanism of Action: The exact mechanism is not fully understood, but it is believed to work by binding to serotonin receptors, specifically 5-HT${1B}$ and 5-HT${1D}$ receptors, which are located on intracranial blood vessels and nerve endings. By activating these receptors, Eletriptan causes the following effects:

• Vasoconstriction: It constricts the dilated cranial arteries and veins that are thought to contribute to the pain of a migraine attack.

• Inhibition of Neuropeptide Release: It inhibits the release of pro-inflammatory neuropeptides from nerve endings in the trigeminal system, which helps to reduce the pain and associated symptoms of a migraine.