Description

This is a fixed-dose combination medication containing azilsartan and amlodipine. Azilsartan is an angiotensin II receptor blocker (ARB), and amlodipine is a calcium channel blocker (CCB). The combination is designed to provide a more effective and stable reduction in blood pressure than either drug used alone.

Indication

This medication is indicated for the treatment of hypertension (high blood pressure). It is typically used for patients whose blood pressure is not adequately controlled by a single medication.

Mechanism of Action

The drug works through a dual mechanism to lower blood pressure:

1. Azilsartan is an Angiotensin II Receptor Blocker (ARB). It works by blocking the angiotensin II type 1 (AT1) receptors. Angiotensin II is a powerful hormone that causes blood vessels to constrict and stimulates the release of aldosterone, which leads to sodium and water retention. By blocking the effects of angiotensin II, azilsartan causes blood vessels to relax and widen, reducing blood pressure.
2. Amlodipine is a Calcium Channel Blocker (CCB). It inhibits the influx of calcium ions into the smooth muscle cells of the blood vessels. This causes the blood vessels to relax and dilate, particularly the arteries, which reduces peripheral vascular resistance and lowers blood pressure.

The combination of these two mechanisms provides a synergistic effect, offering a more significant reduction in blood pressure than either component alone.