Description: Anastrozole is a non-steroidal drug that belongs to a class of medications called aromatase inhibitors. It is used as a first-line treatment for hormone-receptor-positive breast cancer in postmenopausal women.

Indication: It is indicated for the treatment of hormone-receptor-positive early breast cancer in postmenopausal women. It is also used to treat advanced or metastatic hormone-receptor-positive breast cancer in postmenopausal women.

Mechanism of Action: Anastrozole works by blocking the enzyme aromatase, which is responsible for converting androgens (male hormones) into estrogens (female hormones) in the body’s tissues, particularly in the adrenal glands and fatty tissue. By inhibiting aromatase, anastrozole significantly reduces the amount of estrogen circulating in the body. In hormone-receptor-positive breast cancers, estrogen can stimulate the growth of cancer cells. By lowering estrogen levels, anastrozole helps to slow or stop the growth of these cancer cells.