Description
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- Description
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Rosuvastatin Calcium is a potent medication that belongs to the class of drugs known as statins or HMG-CoA reductase inhibitors.
It is a synthetic lipid-lowering agent used to reduce high cholesterol and triglyceride levels. Rosuvastatin is considered one of the most effective statins at lowering LDL (“bad”) cholesterol. The “calcium” in its name refers to the salt form used to ensure the drug’s stability and solubility for oral administration. Indications
Rosuvastatin Calcium is used for a variety of conditions related to high cholesterol and the prevention of cardiovascular disease.
Its primary indications include: - Primary Hypercholesterolemia: It is a first-line therapy to lower high levels of total cholesterol and LDL (“bad”) cholesterol.
- Hypertriglyceridemia: It is effective at lowering high levels of triglycerides.
- Cardiovascular Risk Reduction: It is prescribed to reduce the risk of heart attack, stroke, and the need for revascularization procedures in patients with or without existing heart disease, but who have multiple risk factors.
- Atherosclerosis: It is used to slow the progression of atherosclerosis (the buildup of plaque in arteries).
Mechanism of Action
Rosuvastatin’s therapeutic effect is primarily a result of its ability to inhibit a key enzyme in the cholesterol synthesis pathway.
- Enzyme Inhibition: Rosuvastatin works in the liver by competitively inhibiting the enzyme HMG-CoA reductase.
This enzyme is the rate-limiting step in the mevalonate pathway, which is the body’s primary way of synthesizing cholesterol.
- Reduced Cholesterol Production: By blocking this enzyme, rosuvastatin significantly reduces the amount of cholesterol the liver produces.
- Increased LDL Receptor Activity: The liver, in response to the reduced internal cholesterol production, increases the number of LDL receptors on the surface of its cells.
These receptors are responsible for binding to and removing LDL cholesterol from the bloodstream.
- Decreased LDL and Triglycerides: The increased number of LDL receptors leads to a significant reduction in the amount of circulating LDL (“bad”) cholesterol.
Rosuvastatin also causes a modest increase in HDL (“good”) cholesterol and a decrease in triglycerides. - By reducing the amount of circulating LDL cholesterol, rosuvastatin helps to prevent the formation of atherosclerotic plaque, which is the primary cause of heart attacks and strokes. Its high efficacy and long half-life allow for potent cholesterol reduction with once-daily dosing.
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