Description

Calcium Dobesilate is a synthetic vasoprotective agent. It is the calcium salt of dobesilic acid and is known for its ability to regulate impaired capillary function.

Indications

Calcium Dobesilate Monohydrate is primarily used to treat conditions involving disorders of the blood vessels, particularly the microcirculation (the network of the smallest blood vessels). Its key indications include:

• Chronic Venous Insufficiency (CVI): A condition where veins, particularly in the legs, have difficulty returning blood to the heart, leading to symptoms like pain, swelling (edema), heaviness, and cramps.
• Diabetic Retinopathy: A complication of diabetes that damages the blood vessels in the retina, potentially leading to vision loss.
• Hemorrhoidal Syndrome: The symptoms associated with hemorrhoids, which are swollen and inflamed veins in the rectum and anus.
• Microcirculation Disorders: Various conditions where blood flow in the smallest vessels is compromised.

Mechanism of Action

The mechanism of action of Calcium Dobesilate Monohydrate is multifaceted, primarily focusing on improving the health and function of blood vessels, especially the capillaries. It is believed to work through several pathways:

• Regulation of Capillary Permeability: It acts on the capillary walls to reduce their fragility and permeability, which prevents the leakage of fluid and proteins into surrounding tissues. This helps to reduce edema (swelling) and other symptoms of vascular disorders.
• Improvement of Blood Rheology: It helps to improve blood flow by decreasing blood hyperviscosity (thickness) and inhibiting platelet aggregation.
• Anti-inflammatory and Antioxidant Effects: The drug has been shown to have anti-inflammatory properties, reducing the inflammatory response in the vascular system. It also acts as an antioxidant, neutralizing free radicals that can damage blood vessel walls.
• Vascular Endothelial Protection: It helps to stabilize and protect the endothelial cells that line blood vessels, which is crucial for maintaining proper vascular function.