Mechanism of Action: This is a combination drug. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting enzymes called COX-1 and COX-2. Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production. The combination helps to relieve pain while protecting the stomach from the ulcer-causing effects of naproxen.

Indications: It is used to treat pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in patients who are at risk for developing stomach ulcers.